| BOGER JOSHUA SDirector, 10% Owner | Open-market purchaseNon-derivative security10b5-1 plan not indicated | 955,414 | $3.14 | $2,999,999.96 | 1,795,865 | Jun 11, 2026 | Jun 15, 2026SEC filing |
| BOGER JOSHUA SDirector, 10% Owner | Open market purchaseDerivative security10b5-1 plan not indicated | 955,414 | — | — | 955,414 | Jun 11, 2026 | Jun 15, 2026SEC filing |
| BOGER JOSHUA SDirector, 10% Owner | Open market purchaseDerivative security10b5-1 plan not indicated | 955,414 | — | — | 955,414 | Jun 11, 2026 | Jun 15, 2026SEC filing |
| ALAM JOHN JCEO & President, Director, 10% Owner | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| BOGER JOSHUA SDirector, 10% Owner | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| Gregoire SylvieDirector, 10% Owner | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| Hollingsworth Jane HDirector | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| Poulton Jeffrey V.Director | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| Quigley DavidDirector | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| Sabbagh MarwanDirector | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| ZAVRL FRANKDirector | Grant / awardDerivative security10b5-1 plan not indicated | 8,150 | — | — | 8,150 | Jun 8, 2026 | Jun 10, 2026SEC filing |
| ALAM JOHN JCEO & President, Director, 10% Owner | Grant / awardDerivative security10b5-1 plan not indicated | 75,000 | — | — | 75,000 | Feb 11, 2026 | Feb 13, 2026SEC filing |
| Blackburn KellyEVP, Clinical Development | Grant / awardDerivative security10b5-1 plan not indicated | 30,000 | — | — | 30,000 | Feb 11, 2026 | Feb 13, 2026SEC filing |
| De Rosch MarkEVP, RA and GA and PgM | Grant / awardDerivative security10b5-1 plan not indicated | 30,000 | — | — | 30,000 | Feb 11, 2026 | Feb 13, 2026SEC filing |
| ELDER WILLIAM ROBERTCFO, GC & Secretary | Grant / awardDerivative security10b5-1 plan not indicated | 30,000 | — | — | 30,000 | Feb 11, 2026 | Feb 13, 2026SEC filing |
| Gregoire SylvieDirector, 10% Owner | Grant / awardDerivative security10b5-1 plan not indicated | 75,000 | — | — | 75,000 | Feb 11, 2026 | Feb 13, 2026SEC filing |
| Winton MatthewChief Commercial and Business | Grant / awardDerivative security10b5-1 plan not indicated | 30,000 | — | — | 30,000 | Feb 11, 2026 | Feb 13, 2026SEC filing |